CRLF2 anticorps (PE)

N° du produit ABIN749748

Cet anticorps anti-CRLF2 est un anticorps Lapin Polyclonal détectant CRLF2 dans IF (p). Adapté pour Humain.

Aperçu rapide pour CRLF2 anticorps (PE) (ABIN749748)

Antigène: CRLF2 (Cytokine Receptor-Like Factor 2 (CRLF2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CRLF2 est conjugé à/à la PE

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-CRLF2 anticorps (PE)

Specificité: Excitation / Emission Wavelengths: 565nm/578nm

Purification: purified by Protein A

Immunogène: KLH conjugated synthetic peptide derived from human CRLF2

Isotype: IgG

Information d'application

Commentaires:

Excitation / Emission wavelength: 496nm / 578nm

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 µg/µL

Buffer: Aqueous buffered solution containing 100 µg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 4 °C for 12 months

Date de péremption: 12 months

Détails sur CRLF2

Antigène: CRLF2 (Cytokine Receptor-Like Factor 2 (CRLF2))

Autre désignation: CRLF2

Sujet: TSLPR is a type I membrane receptor that forms a functional heterodimeric complex with IL7R to bind TSLP. The TSLP R contains a WSXWS motif required for proper protein folding and a box1 motif important for association with the JAKs. TSLPR has a predicted molecular weight approximately 41 kD, and two further isoforms have been reported that are produced by alternative splicing. The TSLPR is expressed preferentially in myeloid cells including dendritic cells and activated monocytes, and is weakly expressed in T cells. Expression has also been reported in heart, skeletal muscle, and kidney tissues. TSLP binding to the heterodimeric functional receptor (TSLPR and IL7R) activates JAK2, STAT3 and STAT5 to stimulate cell proliferation. Ligand receptor interactions haves been implicated in the development of the hematopoietic system, dendritic cell maturation, and the maintenance and polarization of human Th2 memory T cells in allergic diseases.

Poids moléculaire: 41kDa

ID gène: 64109